JOHN WILLIAMSON

Academic Background:

• B.S., N.C. State College; M.S., Cornell University; Ph.D., University of Georgia
• Postdoctoral Fellow, Oak Ridge National Laboratory
• Postdoctoral Fellow, University of California, Riverside
• Professor of Biology, University of Calgary
• Professor of Biology, Davidson College

Professional Organizations: Genetics Society of America

Recent Publications (with students):

• Bowen, L. and J. H. Williamson. 1994. Adriamycin does not inhibit malic enzyme, 6-PGD or isocitrate dehydrogenase from Drosophila. Drosophila Information Service 75.
• Chang, C. and J. H. Williamson. 1994. The effects of steroids on NADP-dependent enzymes of Drosophila melanogaster. Drosophila Information Service 75.
• Srinivason, A. and J.H. Williamson. 1994. Inhibition of Drosophila glucose-6-phosphate dehydrogenase by palmitoyl Coenzyme A. Drosophila Information Service 75.
• Wegulo, S. and J.H. Williamson. 1994. Inhibition of Drosophila malic enzyme by 1,3,5 (10)-estratrien-2,3-diol-20-one. Drosophila Information Service 75.

Current Research Interests:

My research interests concern a group of enzymes in Drosophila melanogaster that require NADP+ as a coenzyme. These are: Malic Enzyme, Glucose-6-Phosphate Dehydrogenase, 6-Phophogluconate Dehydrogenase and Isocitrate Dehydrogenase (the soluble form). These enzymes play crucial roles in metabolism, generating reducing equivalents for lipid biosynthesis. The two "glucose" enzymes assays are central to the pentose pathway and the IDH is one of the major enzymes assayed immediately after cardiac infarction. Specifically, my research activities include the effects of modifier genes on G6PD and 6PGD activities, the structural genes of which are located on the X chromosome

Current Teaching Interests:

Introductory Biology; Genetics; Genetics, Society and Decisions; Biochemical Genetics