This seminar, "Some Reactions Require Commitment - Processivity in Cytochrome P450-Steroid Enzymology," will describe work focusing on human cytochrome P450 11B2, which is responsible for the formation of aldosterone, the major human mineralocorticoid steroid. Human cytochrome P450 enzymes are essential catalysts for the metabolism of normal endogenous ligands like steroids, fatty acids, and vitamins as well as compounds foreign to the body like environment toxicants. By investigating the reactions of human P450 11B2 a model has been developed to describe the degree of processivity of the cytochrome P450 11B2 reactions. Free and open to the public.
Wall Academic Center WALL-210 Classroom
Yates, Alexis C