Dr. Amelia Fuller '02, Department of Chemistry, Santa Clara University, will discuss "New Peptidomimetic Molecules for Sensing Organic Molecules in Water." Fuller's research is aimed at understanding interactions between small organic molecules and water-soluble peptoids, N-substituted glycine oligomers. Peptoids are an attractive peptidomimetic scaffold for this application; their sequence-specific preparation is straightforward and accommodates the synthesis of a wide diversity of analogs, including those that exhibit stable structural features in aqueous solution. New results to be presented here will demonstrate that peptoids with modulated self-association constitute a suite of supramolecular hosts that are able to detect and differentiate small molecules. This is a promising new application for peptoids, and an exciting new approach to the detection of small molecules in aqueous media.
Wall Academic Center Hamilton W. McKay Atrium
Yates, Alexis C